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Abstract <p>Methomyl (MET), a broad spectrum carbamate insecticide, isused in agriculture to combat ectoparasites. Baicalin (BAI) is aflavoneglycoside with anti-inflammatory, anticarcinogen and antioxidant effectsand is widely found in the plants of the genus <i>Scutellaria</i>.The aim of this study was to determine the effects of BAI on MET-inducedsubacute intoxication in rats. For this, 48 rats were randomly dividedinto six groups: I—control; II—BAI 1 (50 mg/kg of body weight (bw))group; III—BAI 2 (100 mg/kg bw) group; IV—MET (4 mg/kg bw) group; V—BAI1 + MET group; VI—BAI 2 + MET group. The MET and BAI were administered(via gavage) once a day during 28 days after which blood samples weretaken for biochemical analysis and the tissues of liver, kidneyand lung were histopathologically examined. It was found that inthe MET-treated group the levels of blood urea nitrogen (BUN), creatinine,uric acid, triglyceride, cholesterol, lactate dehydrogenase (LDH),aspartate transaminase (AST), alanine transaminase (ALT), alkalinephosphatase (ALP) were significantly increased while albumin andtotal protein levels were decreased in the serum compared to thecontrol. Also, glutathione (GSH), glutathione peroxidase (GPx),glutathione reductase (GR), glutathione <i>S</i>-transferase(GST), superoxide dismutase (SOD) and catalase (CAT) decreased butmalondialdehyde (MDA) increased in blood and tissues in the MET-treatedgroup. When the MET-treated group was histopathologically comparedwith the control group, degeneration in liver and kidney tissuesand inflammation in lung tissue were observed. Treatment with BAIresulted in a significant increase of GSH, GPx, GR, GST, SOD, andCAT but a decrease of the MDA levels (<i>p</i> &lt; 0.05).The administration of BAI in two different doses along with METreduced tissue degeneration and inflammation in a dose-dependentmanner. The results of histopathological analysis were consistent withthe biochemical data. This suggests that BAI can ameliorate oxidativestress and tissue damage by increasing the levels of antioxidantsand reducing reactive oxygen species (ROS) in MET-treated rats.</p>

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Baicalin Attenuates Methomyl-Induced Oxidative Stress and Tissue Damage in Liver, Kidney, Lung, and Blood of Rats

  • 期刊论文

  • 发表日期：

    2026年4月19日

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  • M. Y. Tekeli,
  • F. Koc,
  • S. Calimli,
  • M. O. Karayigit,
  • C. Aslan

摘要

Abstract

Methomyl (MET), a broad spectrum carbamate insecticide, isused in agriculture to combat ectoparasites. Baicalin (BAI) is aflavoneglycoside with anti-inflammatory, anticarcinogen and antioxidant effectsand is widely found in the plants of the genus Scutellaria.The aim of this study was to determine the effects of BAI on MET-inducedsubacute intoxication in rats. For this, 48 rats were randomly dividedinto six groups: I—control; II—BAI 1 (50 mg/kg of body weight (bw))group; III—BAI 2 (100 mg/kg bw) group; IV—MET (4 mg/kg bw) group; V—BAI1 + MET group; VI—BAI 2 + MET group. The MET and BAI were administered(via gavage) once a day during 28 days after which blood samples weretaken for biochemical analysis and the tissues of liver, kidneyand lung were histopathologically examined. It was found that inthe MET-treated group the levels of blood urea nitrogen (BUN), creatinine,uric acid, triglyceride, cholesterol, lactate dehydrogenase (LDH),aspartate transaminase (AST), alanine transaminase (ALT), alkalinephosphatase (ALP) were significantly increased while albumin andtotal protein levels were decreased in the serum compared to thecontrol. Also, glutathione (GSH), glutathione peroxidase (GPx),glutathione reductase (GR), glutathione S-transferase(GST), superoxide dismutase (SOD) and catalase (CAT) decreased butmalondialdehyde (MDA) increased in blood and tissues in the MET-treatedgroup. When the MET-treated group was histopathologically comparedwith the control group, degeneration in liver and kidney tissuesand inflammation in lung tissue were observed. Treatment with BAIresulted in a significant increase of GSH, GPx, GR, GST, SOD, andCAT but a decrease of the MDA levels (p < 0.05).The administration of BAI in two different doses along with METreduced tissue degeneration and inflammation in a dose-dependentmanner. The results of histopathological analysis were consistent withthe biochemical data. This suggests that BAI can ameliorate oxidativestress and tissue damage by increasing the levels of antioxidantsand reducing reactive oxygen species (ROS) in MET-treated rats.