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Abstract <p>The study investigates the dynamics of autonomic cardiac controlin healthy volunteers with different baseline hypoxic resistanceduring acute normobaric hypoxia. The primary focus was on changesin the autonomic nervous system, assessed through the heart ratevariability (HRV) indices and the pre-ejection period (PEP). Thestudy involved 62 volunteers (24 men and 36 women, mean age 18&#xa0;[18;19] years) retrospectively divided into two groups: hypoxia-resistant(<i>n</i> = 16) and hypoxia-sensitive(<i>n</i> = 46). A hypoxic test (HT)was performed on the ReOxy device, assessing the dynamics of HRV,PEP, blood pressure (BP), and heart rate (HR) before, during, andafter testing. The overall response to hypoxia was manifested asa significant decrease in PEP and the HRV indices RMSSD and pNN50, indicatingsympathetic activation and reduced vagal tone. The recovery periodshowed an increase in these indices and a decrease in BP. Resistantvolunteers initially had higher baseline values of RMSSD, pNN50,and high-frequency component power (HF). During HT, they exhibiteda lesser degree of desaturation (ΔSpO<sub>2</sub> =–14.9 [–16.7; –12.6]) compared to the sensitive group (ΔSpO<sub>2</sub> =–19.2 [–19.6; –18.4]), with a lesser increase in HR, though a more pronounceddecrease in PEP. During recovery, the resistant group demonstratedhigher indices of parasympathetic activity alongside a decreasein HR. The study confirms that high hypoxic resistance is associatedwith an initially pronounced parasympathetic tone, an adequate sympatheticactivation in response to a stimulus, and a vagal rebound duringrecovery. Sensitive individuals exhibited vagal depression and prolongedsympathetic activation, which correlates with desaturation. Theobtained data justify the importance of considering autonomic sensitivity whenapplying hypoxia adaptation techniques.</p>

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Dynamics of Autonomic Cardiac Control during Acute Normobaric Hypoxia Modeling in Volunteers with Varying Baseline Hypoxic Resistance

  • 期刊论文

  • 发表日期：

    2025年12月19日

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  • A. S. Mikhalishchina,
  • Ya. V. Vasina,
  • E. D. Zagayny,
  • Ya. S. Tyukin,
  • O. S. Glazachev

摘要

Abstract

The study investigates the dynamics of autonomic cardiac controlin healthy volunteers with different baseline hypoxic resistanceduring acute normobaric hypoxia. The primary focus was on changesin the autonomic nervous system, assessed through the heart ratevariability (HRV) indices and the pre-ejection period (PEP). Thestudy involved 62 volunteers (24 men and 36 women, mean age 18 [18;19] years) retrospectively divided into two groups: hypoxia-resistant(n = 16) and hypoxia-sensitive(n = 46). A hypoxic test (HT)was performed on the ReOxy device, assessing the dynamics of HRV,PEP, blood pressure (BP), and heart rate (HR) before, during, andafter testing. The overall response to hypoxia was manifested asa significant decrease in PEP and the HRV indices RMSSD and pNN50, indicatingsympathetic activation and reduced vagal tone. The recovery periodshowed an increase in these indices and a decrease in BP. Resistantvolunteers initially had higher baseline values of RMSSD, pNN50,and high-frequency component power (HF). During HT, they exhibiteda lesser degree of desaturation (ΔSpO2 =–14.9 [–16.7; –12.6]) compared to the sensitive group (ΔSpO2 =–19.2 [–19.6; –18.4]), with a lesser increase in HR, though a more pronounceddecrease in PEP. During recovery, the resistant group demonstratedhigher indices of parasympathetic activity alongside a decreasein HR. The study confirms that high hypoxic resistance is associatedwith an initially pronounced parasympathetic tone, an adequate sympatheticactivation in response to a stimulus, and a vagal rebound duringrecovery. Sensitive individuals exhibited vagal depression and prolongedsympathetic activation, which correlates with desaturation. Theobtained data justify the importance of considering autonomic sensitivity whenapplying hypoxia adaptation techniques.