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Abstract <p>The aim of the study was to test the hypothesis of a possibleprotective effect of empagliflozin, an SGLT2 blocker, on the functionalstate of skin microvessels in a rat early-stage chronic kidney disease (CKD)model. In the NE group rats (<i>n </i>=10), kidney dysfunction was induced by a combination of 3/4&#xa0;nephrectomyand a high-sodium dietary load (4% NaCl); animals in the EMPA group(<i>n </i>= 10), after CKD modeling,received 1 mg/kg of empagliflozin; control rats in the SO group(<i>n </i>= 10) underwent a sham operationand fed a standard diet with normal salt content. Baseline skinmicrocirculation parameters and their changes in response to acetylcholine(ACh) and sodium nitroprusside (SNP) were assessed using laser Dopplerflowmetry; skin microvascular tone was calculated by a wavelet analysis.It was shown that in CKD, EMPA had no effect on the levels of arterialpressure and uremia, as well as the mean skin microcirculation index(MCI). At the same time, EMPA prevented a nephrectomy-specific increasein microvascular tone in the endothelial, neurogenic, and myogenicranges. ACh iontophoresis increased the MCI by 59.4 ± 4.4% in theEMPA group, by 38.0 ± 8.3% in the NE group, and by 60.6 ± 5.7% inthe SO group, while SNP increased it by 53.0 ± 3.5%, 36.4 ± 6.0%,and 68.5 ± 8.7%, respectively. Thus, EMPA prevented the enhancementof tonic influences on the skin microcirculatory vessels in thestudied ranges, as well as the development of microvascular endothelialdysfunction, in a rat early-stage CKD model, preserving the vascularreactivity of the skin microcirculatory bed to vasodilator agentsat the level of control animals.</p>

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Effect of Empagliflozin on the Functional State of Skin Microcirculatory Vessels in Wistar Rats with Kidney Dysfunction

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • G. T. Ivanova,
  • O. N. Beresneva,
  • M. H. Khasun,
  • A. Sh. Rumyantsev,
  • A. G. Kucher

摘要

Abstract

The aim of the study was to test the hypothesis of a possibleprotective effect of empagliflozin, an SGLT2 blocker, on the functionalstate of skin microvessels in a rat early-stage chronic kidney disease (CKD)model. In the NE group rats (n =10), kidney dysfunction was induced by a combination of 3/4 nephrectomyand a high-sodium dietary load (4% NaCl); animals in the EMPA group(n = 10), after CKD modeling,received 1 mg/kg of empagliflozin; control rats in the SO group(n = 10) underwent a sham operationand fed a standard diet with normal salt content. Baseline skinmicrocirculation parameters and their changes in response to acetylcholine(ACh) and sodium nitroprusside (SNP) were assessed using laser Dopplerflowmetry; skin microvascular tone was calculated by a wavelet analysis.It was shown that in CKD, EMPA had no effect on the levels of arterialpressure and uremia, as well as the mean skin microcirculation index(MCI). At the same time, EMPA prevented a nephrectomy-specific increasein microvascular tone in the endothelial, neurogenic, and myogenicranges. ACh iontophoresis increased the MCI by 59.4 ± 4.4% in theEMPA group, by 38.0 ± 8.3% in the NE group, and by 60.6 ± 5.7% inthe SO group, while SNP increased it by 53.0 ± 3.5%, 36.4 ± 6.0%,and 68.5 ± 8.7%, respectively. Thus, EMPA prevented the enhancementof tonic influences on the skin microcirculatory vessels in thestudied ranges, as well as the development of microvascular endothelialdysfunction, in a rat early-stage CKD model, preserving the vascularreactivity of the skin microcirculatory bed to vasodilator agentsat the level of control animals.