Abstract <p>Perinatal hypoxia is one of the most common pathologies inearly ontogenesis, which can exert a programming effect on the functioningof vascular system. The latter has been shown for pulmonary arteries,as well as in a few studies on systemic arteries. However, thereare no data on the delayed influence of perinatal hypoxia on thefunctioning of the hemodynamically significant vascular region of skeletalmuscles. In this regard, the aim of this work was to study the delayedeffects of a single normobaric hypoxia in early ontogenesis on thefunctioning of skeletal muscle arteries in adulthood. In this study,2-day-old male Wistar rats were exposed to normobaric hypoxia (8%O₂) for 2 h and then raised to adulthood(11–12 weeks), after which the functional activity of the suralarteries, as well as the level of systolic blood pressure, wereassessed. The contractile responses of the sural arteries to anα₁-adrenoceptor agonist, the endothelium-dependentrelaxation responses to acetylcholine, and the endothelium-independentrelaxation responses to an NO donor did not differ between the Hypoxiaand Control groups. The anticontractile effect of NO and large-conductanceCa²⁺-activated potassium channels (BK_Ca),as well as the procontractile influence of Rho-kinase in the arteries,were not altered in rats that had underwent perinatal hypoxia. Thelevels of systolic blood pressure did not differ between the groups.Thus, short-term normobaric perinatal hypoxia does not lead to delayedchanges in the regulation of sural artery tone and the level ofarterial blood pressure in adult rats.</p>