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Abstract <p>Spinal cord injury (SCI) is a chronic neurological disordercaused by damage to the spinal cord tissues and often accompaniedby severe multisystem complications, autonomic dysfunction, riskof depressive states, a sharp decline in quality of life, and patientdisability. Dopamine plays a crucial role in regulating motor functionsand immune responses, making it a promising target for therapy developmentafter SCI. This review explores the sources of spinal cord dopamine,its role in neuroplasticity, and its influence on neurotrophic factorsand neurogenesis. Dopamine modulates synaptic plasticity throughD1 and D2 receptors, promoting axon growth and synaptogenesis. Itcan also stimulate the synthesis of neurotrophic factors, such asBDNF, GDNF, NGF, EGF, FGF-2, and CNTF, which support neuronal survivaland reduce inflammation. Additionally, dopamine regulates differentiation,myelination, and immune responses by suppressing pro-inflammatorycytokines and enhancing anti-inflammatory processes. Despite itstherapeutic potential, the dual role of dopamine in certain processes,such as angiogenesis suppression, requires further investigation.This review highlights the multifaceted role of dopamine in post-SCIrecovery and its potential for developing new treatment strategies.</p>

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The Effect of Dopamine on Neuroplasticity in Spinal Cord Injury

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • A. A. Chesnokov,
  • D. S. Kalinina,
  • A. E. Makhortykh,
  • D. V. Khuzin,
  • P. E. Musienko

摘要

Abstract

Spinal cord injury (SCI) is a chronic neurological disordercaused by damage to the spinal cord tissues and often accompaniedby severe multisystem complications, autonomic dysfunction, riskof depressive states, a sharp decline in quality of life, and patientdisability. Dopamine plays a crucial role in regulating motor functionsand immune responses, making it a promising target for therapy developmentafter SCI. This review explores the sources of spinal cord dopamine,its role in neuroplasticity, and its influence on neurotrophic factorsand neurogenesis. Dopamine modulates synaptic plasticity throughD1 and D2 receptors, promoting axon growth and synaptogenesis. Itcan also stimulate the synthesis of neurotrophic factors, such asBDNF, GDNF, NGF, EGF, FGF-2, and CNTF, which support neuronal survivaland reduce inflammation. Additionally, dopamine regulates differentiation,myelination, and immune responses by suppressing pro-inflammatorycytokines and enhancing anti-inflammatory processes. Despite itstherapeutic potential, the dual role of dopamine in certain processes,such as angiogenesis suppression, requires further investigation.This review highlights the multifaceted role of dopamine in post-SCIrecovery and its potential for developing new treatment strategies.