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Abstract <p>The article provides an overview of current data validatingthe use of a model of olfactory bulbectomy in rodents for studyingmental disorders in humans. Based on the extensive literature andour own findings, we demonstrate the potential of this model asa representation of depression and Alzheimer’s disease, consideringthe alignment of observed changes with modern criteria of validity.In rodents, olfactory bulbectomy causes a whole complex of molecular,structural, and behavioral changes, which cannot optimally modela certain human disease. Here, we discuss the limitations of usingthis model and interpreting its outcomes. Nevertheless, the modelcan be a useful tool for both basic and applied studies of humanbrain pathologies, provided the stated limitations are observed.</p>

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Possibilities and Limitations of Using the Rodent Olfactory Bulbectomy Model

  • 期刊论文

  • 发表日期：

    2025年3月1日

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  • O. A. Nedogreeva,
  • M. Yu. Stepanichev

摘要

Abstract

The article provides an overview of current data validatingthe use of a model of olfactory bulbectomy in rodents for studyingmental disorders in humans. Based on the extensive literature andour own findings, we demonstrate the potential of this model asa representation of depression and Alzheimer’s disease, consideringthe alignment of observed changes with modern criteria of validity.In rodents, olfactory bulbectomy causes a whole complex of molecular,structural, and behavioral changes, which cannot optimally modela certain human disease. Here, we discuss the limitations of usingthis model and interpreting its outcomes. Nevertheless, the modelcan be a useful tool for both basic and applied studies of humanbrain pathologies, provided the stated limitations are observed.