Scholarlink

Abstract <p>This review addresses a hypothetical evolutionary scenariobased on the self-organization of replicating RNA molecules, andsubstantiates their link with modern regulatory systems of noncodingRNAs (ncRNAs). We systematize modern scientific data that considerself-organizing RNA molecules as key evolutionary units of the prebioticstage of life development, and analyze modern models of the formationof chemical RNA precursors in prebiotic conditions, as well as theirfurther polymerization into functional RNAs. The analysis of putativescenarios for the formation of emergent states reveals the regulatoryfunction of early RNA replicators and their role in the developmentof sophisticated biological systems. The widespread prevalence ofregulatory ncRNAs across all groups of living organisms suggests theirancient origin. It is highly likely that modern RNA switches, groupII introns, and spliceosomal introns, which are the source of mostncRNAs, originate from a common ancient RNA infrastructure, whichmay have ensured a coordination of replication, compartmentalizationand metabolism during the early stages of evolution. By combininginsights from biochemistry, genomics, and evolutionary biology, ouranalysis offers a comprehensive perspective on the molecular mechanismsunderlying the origin and diversification of ncRNAs.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Non-Coding RNAs and Their Regulatory Systems: Evolutionary Origin and Putative Link with Ribozymes

  • 期刊论文

  • 发表日期：

    2025年3月1日

查看全文
  • V. A. Markelov,
  • L. Z. Akhmadishina,
  • V. A. Solntsev,
  • K. V. Danilko,
  • G. F. Korytina

摘要

Abstract

This review addresses a hypothetical evolutionary scenariobased on the self-organization of replicating RNA molecules, andsubstantiates their link with modern regulatory systems of noncodingRNAs (ncRNAs). We systematize modern scientific data that considerself-organizing RNA molecules as key evolutionary units of the prebioticstage of life development, and analyze modern models of the formationof chemical RNA precursors in prebiotic conditions, as well as theirfurther polymerization into functional RNAs. The analysis of putativescenarios for the formation of emergent states reveals the regulatoryfunction of early RNA replicators and their role in the developmentof sophisticated biological systems. The widespread prevalence ofregulatory ncRNAs across all groups of living organisms suggests theirancient origin. It is highly likely that modern RNA switches, groupII introns, and spliceosomal introns, which are the source of mostncRNAs, originate from a common ancient RNA infrastructure, whichmay have ensured a coordination of replication, compartmentalizationand metabolism during the early stages of evolution. By combininginsights from biochemistry, genomics, and evolutionary biology, ouranalysis offers a comprehensive perspective on the molecular mechanismsunderlying the origin and diversification of ncRNAs.