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Abstract <p>Here, we investigated the long-term effects of assisted reproductivetechnologies (ARTs), such as in vitro embryo culture and embryotransfer, on behavior and brain development in B6.Cg-Tg mice, a modelof Parkinson’s disease (PD), and wild-type C57BL/6 mice. Male offspringobtained via ARTs were compared to those conceived naturally. Atthe age of 6 months, mice were assessed for anxiety in the elevatedplus maze and additionally had their body and brain mass measured.It was found that naturally conceived B6.Cg-Tg mice exhibited loweranxiety levels and larger brain mass compared to wild-type mice.The use of ARTs led to a decreased brain mass in B6.Cg-Tg offspringand significantly decreased their anxiety levels compared to controls.In wild-type C57BL/6 mice, ARTs caused no significant changes inbrain mass or anxiety levels. The results demonstrate the impactof ARTs on behavior and brain development in offspring, particularlyin those genetically predisposed to neurodegenerative diseases.These results accentuate the necessity of further studies of thelong-term effects of ARTs, especially in the context of their influenceon neurodevelopment and behavior, which has important medical implications.</p>

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Effects of Assisted Reproductive Technologies on Behavior and Brain Development in a Mouse Model of Parkinson’s Disease

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • I. N. Rozhkova,
  • V. S. Kozeneva,
  • E. Yu. Brusentsev,
  • T. A. Rakhmanova,
  • N. A. Shavshaeva,
  • S. G. Afanasova,
  • T. N. Igonina,
  • S. V. Okotrub,
  • V. A. Naprimerov,
  • S. Ya. Amstislavsky

摘要

Abstract

Here, we investigated the long-term effects of assisted reproductivetechnologies (ARTs), such as in vitro embryo culture and embryotransfer, on behavior and brain development in B6.Cg-Tg mice, a modelof Parkinson’s disease (PD), and wild-type C57BL/6 mice. Male offspringobtained via ARTs were compared to those conceived naturally. Atthe age of 6 months, mice were assessed for anxiety in the elevatedplus maze and additionally had their body and brain mass measured.It was found that naturally conceived B6.Cg-Tg mice exhibited loweranxiety levels and larger brain mass compared to wild-type mice.The use of ARTs led to a decreased brain mass in B6.Cg-Tg offspringand significantly decreased their anxiety levels compared to controls.In wild-type C57BL/6 mice, ARTs caused no significant changes inbrain mass or anxiety levels. The results demonstrate the impactof ARTs on behavior and brain development in offspring, particularlyin those genetically predisposed to neurodegenerative diseases.These results accentuate the necessity of further studies of thelong-term effects of ARTs, especially in the context of their influenceon neurodevelopment and behavior, which has important medical implications.