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Abstract <p>Spreading depolarizations (SDs) often accompany epileptiformdischarges and participate in their termination. However, the factorsthat determine the occurrence of SD during epileptic seizures remain poorlyunderstood. In this study, we investigated the influence of ageon this phenomenon by performing multichannel intracortical recordingsof electrical signals at different depths of the somatosensory cortex inrats during generalized epileptic discharges induced by flurothylinhalation. We found that in juvenile rats (1–2 months old), SDfrequently accompanied flurothyl-induced seizures, occurring inalmost half of the cases. In contrast, SD events were much lessfrequent in immature rats (less than 3 weeks old) and adult rats(older than 3 months). In all age groups, SD originated in the superficialcortical layers and propagated downward into deeper layers. However,the depth of SD penetration was also age dependent: SDs spread deeperin juvenile rats compared to immature and adult animals. Thus, thepropensity for SD during flurothyl-induced seizures follows a bell-shapedage profile, with the highest frequency and deepest propagationobserved in juvenile animals. These findings underscore age as acritical determinant of the occurrence and characteristics of SDduring epileptiform activity in the cortex.</p>

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Age-Related Changes in Spreading Depolarization during Generalized Epileptiform Activity Induced by Flurothyl

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • G. F. Zakirova,
  • K. A. Chernova,
  • D. E. Vinokurova,
  • R. N. Khazipov,
  • A. V. Zakharov

摘要

Abstract

Spreading depolarizations (SDs) often accompany epileptiformdischarges and participate in their termination. However, the factorsthat determine the occurrence of SD during epileptic seizures remain poorlyunderstood. In this study, we investigated the influence of ageon this phenomenon by performing multichannel intracortical recordingsof electrical signals at different depths of the somatosensory cortex inrats during generalized epileptic discharges induced by flurothylinhalation. We found that in juvenile rats (1–2 months old), SDfrequently accompanied flurothyl-induced seizures, occurring inalmost half of the cases. In contrast, SD events were much lessfrequent in immature rats (less than 3 weeks old) and adult rats(older than 3 months). In all age groups, SD originated in the superficialcortical layers and propagated downward into deeper layers. However,the depth of SD penetration was also age dependent: SDs spread deeperin juvenile rats compared to immature and adult animals. Thus, thepropensity for SD during flurothyl-induced seizures follows a bell-shapedage profile, with the highest frequency and deepest propagationobserved in juvenile animals. These findings underscore age as acritical determinant of the occurrence and characteristics of SDduring epileptiform activity in the cortex.