Molecular Genetic Markers of Neuroglia in Traumatic Brain Injury and Their Use for the Functional Assessment of Sportsmen
摘要
Neuroglia performs multiple important physiological functions,including maintenance of brain homeostasis and metabolism, neuroprotectionand modulation of neurotransmission. Studying the role of neurogliais essential for understanding the pathogenesis of neurodegenerativediseases, as well as nervous tissue repair in inflammation or traumaticbrain injuries, not infrequent in sports. However, it is difficultto analyze the processes occurring in neuroglial cells because oftheir high heterogeneity and no system of biomarkers allowing unambiguousassessment of the nervous system’s functional state as a whole.Here we analyze the data on clinically and biologically significantmolecular genetic markers of different types of neuroglia and discussthe prospects for their use in sports physiology, including the functionalassessment of athletes with TBI of varying severity and other typesof sports-related traumas.