Tryptophan Signaling Molecules in Children with Different Developmental Dynamics of Obesity

The high incidence of childhood obesity is a big healthcarechallenge worldwide, which is fraught with the development of notonly numerous somatic comorbidities but also children’s social maladaptation. Searchingfor early biochemical markers of obesity stabilization and its progressionat an older age is very important for identifying risk groups andpreventing the development of obesity and its complications. Ourstudy showed that the child’ sex, which is often disregarded inthese situations, should necessarily be considered when assessingthe developmental dynamics of obesity. Whereas in girls, a decreasein serum serotonin concentrations may serve as a marker of obesitystabilization/progression, in boys, this tendency can be predictedby reduced serum indole-3-acrylate levels. In both sexes, elevatedfecal indole-3-carboxaldehyde levels can be indicative of obesitystabilization/progression.