The Synergistic Trio of Metabolic Master Regulators Sustaining a Vicious Circle of Pathological Processes in Post-Traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is a maladaptive responseto the exposure of an extraordinary-intensity stressor. The animaland human body responds to any external challenges at the systemic, organismaland cellular levels. In stress-sensitive individuals, the collaborationof stress-implementing and stress-limiting systems is compromised,causing the transformation of behavior, cognitive abilities andother functions of the central nervous system. It is commonly acceptednow that changes in the abundance and repertoire of the intestinalmicrobiota play an important role in the pathogenesis of PTSD. Inthis regard, the methods of improving the microflora are high onthe agenda. Analyzing the literature data, we came to the conclusionthat metabolic, somatic and mental health largely depends on thecoordinated functioning of the key interdependent metabolic components:hepatobiliary system, intestinal microbiota and, as we believe,the state of mast cells. Close scrutiny of the interplay of these componentswill help identify new therapeutic targets and the most effectivemethods to treat PTSD.