Zebrafish As a Promising Experimental Model of Traumatic Brain Injury
摘要
Traumatic brain injury (TBI) involves multiple types of physicalbrain lesions. TBI is a highly heterogeneous clinical conditionwhose symptoms include cognitive, motor and emotional deficits,as well as neurodegeneration and neuroinflammation. TBI modelingin animals plays a key role in studying its pathogenetic mechanismsand temporal dynamics, as well as developing new drugs for its treatment. Recently,the use of the zebrafish Danio rerio asa model organism has aroused the growing interest of translationalneurobiology. Zebrafish are now the second most demanded laboratoryanimal species in biomedicine, after mice. Here, we discuss theprospects of using this teleost fish as a model of TBI, as wellas new research trends in this area. We also emphasize the importanceof zebrafish as a highly translational model for studying the molecularmechanisms and neurological disorders in TBI, as well as screeningfor potential therapeutic agents.