Search for Metabolomic Markers of Hypertensive Conditions of Different Genesis: Experimental Study

A personalized approach to the diagnosis and treatment ofarterial hypertension requires a comprehensive analysis of the pathogeneticmechanisms underlying the disease. To determine specific metabolomicmarkers of various hypertensive conditions, four groups of experimentalanimals were studied: WAG rats (normotensive control); ISIAH ratswith inherited stress-induced arterial hypertension (AH); L-NAME-treatedrats with hypertension induced by endothelial dysfunction; rats withhypertension caused by DOCA administration in combination with thesalt loading. Rat blood serum samples were analyzed by NMR spectroscopy.The metabolomic analysis differentiated the hypertensive conditionsof various origins using group-specific blood serum metabolomicbiomarkers. Rats with DOCA-salt hypertension are characterized byincreased concentration of choline. Hypertension associated withendothelial dysfunction induced by L-NAME administration was accompaniedby a decrease in the levels of tyrosine, serine and glycine. Distinctivefeatures of ISIAH rats are increased concentrations of ornithine(urea and nitric oxide cycle), valine, leucine, isoleucine, myo-inositol,glutamate, glutamine (glucose metabolism).