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<p>In this study, the effect of γ-radiation from typical commercial medical sources based on X-ray tubes and linear accelerators on the electrostatic properties of radiosensitizing gold nanoparticles located in a tissue-like medium has been evaluated numerically using a Monte Carlo simulation in the Geant4 software package. It&#xa0;has been shown that for realistic radiation doses, a significant fraction of gold nanoparticles of up to ~10<sup>‒1</sup> can, at least temporarily, change their surface charge sufficiently to convert anionic gold nanoparticles into cationic ones, which can lead to cytotoxic effects.</p>

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Effect of Ionizing Radiation on the Electrostatic Properties of Gold Nanoparticles

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • M. Yu. Azarkin,
  • M. R. Kirakosyan

摘要

In this study, the effect of γ-radiation from typical commercial medical sources based on X-ray tubes and linear accelerators on the electrostatic properties of radiosensitizing gold nanoparticles located in a tissue-like medium has been evaluated numerically using a Monte Carlo simulation in the Geant4 software package. It has been shown that for realistic radiation doses, a significant fraction of gold nanoparticles of up to ~10‒1 can, at least temporarily, change their surface charge sufficiently to convert anionic gold nanoparticles into cationic ones, which can lead to cytotoxic effects.