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Abstract <p>As a potential cartilage substitute, the research on the mechanical properties of hydrogel is crucial. Addressing the issue of traditional hydrogel compression devices' inability to maintain compatibility with cell culture environments, a multi-channel bionic exciter incorporating a six-unit indenter structure was developed in this study. The system integrates high-accuracy linear motors (with the position resolution of 0.002&#xa0;mm) and force transducers (with the accuracy of ±0.01 N) to provide dynamic mechanical stimulation while recording real-time load-displacement data. This instrument enables compression experiments of hydrogels to be conducted under standard cell culture conditions. Experimental validation demonstrated that the instrument was able to accurately simulate predefined mechanical stimuli and record real-time data. This provides a reliable platform for investigating the effects of cyclic mechanical stimulation on hydrogel-mediated cell behavior regulation, it holds significant value for the study of mechanical properties of hydrogels and other biomaterials.</p>

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A Multi-Channel Bionic Exciter for Mechanical Testing of Hydrogels

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Yiming Hu,
  • Pujun Hao,
  • Jingna Liu,
  • Jianzhong Zhu,
  • Chunqiu Zhang

摘要

Abstract

As a potential cartilage substitute, the research on the mechanical properties of hydrogel is crucial. Addressing the issue of traditional hydrogel compression devices' inability to maintain compatibility with cell culture environments, a multi-channel bionic exciter incorporating a six-unit indenter structure was developed in this study. The system integrates high-accuracy linear motors (with the position resolution of 0.002 mm) and force transducers (with the accuracy of ±0.01 N) to provide dynamic mechanical stimulation while recording real-time load-displacement data. This instrument enables compression experiments of hydrogels to be conducted under standard cell culture conditions. Experimental validation demonstrated that the instrument was able to accurately simulate predefined mechanical stimuli and record real-time data. This provides a reliable platform for investigating the effects of cyclic mechanical stimulation on hydrogel-mediated cell behavior regulation, it holds significant value for the study of mechanical properties of hydrogels and other biomaterials.