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Abstract <p>This work presents the results of a study on methods for obtaining elemental boron-10 nanoparticles for use in boron neutron capture therapy. A technology for fabricating solid-state targets from <sup>10</sup>B-enriched powder by free sintering under reduced pressure has been developed. Nanoparticles were synthesized via femtosecond laser ablation in liquid. The influence of the sintering conditions of the targets on the productivity of the process and the characteristics of the resulting nanoparticles was investigated. Colloidal solutions of nanoparticles with average sizes of 50–60 nm and a narrow size distribution were obtained. It was found that optimizing the sintering parameters allows for a twofold increase in the productivity of the laser ablation synthesis. The results demonstrate the potential of the developed approach for producing elemental boron-10 nanoparticles required for effective boron neutron capture therapy.</p>

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Solid Boron Targets Fabricated by Free Sintering for Nanoparticle Synthesis in Boron Neutron Capture Therapy Applications

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • N. V. Karpov,
  • A. A. Fronya,
  • E. I. Mavreshko,
  • S. M. Klimentov,
  • D. I. Tselikov,
  • D. S. Petrunya,
  • V. V. Dubov,
  • P. V. Karpuk,
  • P. S. Sokolov,
  • I. Yu. Komendo,
  • I. N. Zavestovskaya

摘要

Abstract

This work presents the results of a study on methods for obtaining elemental boron-10 nanoparticles for use in boron neutron capture therapy. A technology for fabricating solid-state targets from 10B-enriched powder by free sintering under reduced pressure has been developed. Nanoparticles were synthesized via femtosecond laser ablation in liquid. The influence of the sintering conditions of the targets on the productivity of the process and the characteristics of the resulting nanoparticles was investigated. Colloidal solutions of nanoparticles with average sizes of 50–60 nm and a narrow size distribution were obtained. It was found that optimizing the sintering parameters allows for a twofold increase in the productivity of the laser ablation synthesis. The results demonstrate the potential of the developed approach for producing elemental boron-10 nanoparticles required for effective boron neutron capture therapy.