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Abstract <p>Crystallization in solutions modeling the composition of human blood plasma has been studied as a function of the synthesis time and the solution supersaturation. XRD and IR spectroscopy demonstrate that the crystallized solid phases consist of carbonate hydroxyapatite. Nonstoichiometric water-containing carbonate hydroxyapatite with a small amount of chlorine, the composition of which coincides with human calcificate, forms during syntheses from a model human blood plasma solution. The generalized crystal formula of the synthesized samples is as follows: [Ca<sub>7.66–8.61</sub>Na<sub>0.59–1.24</sub>K<sub>0.11–0.34</sub>Mg<sub>0.08–0.31</sub>Vac<sub>0.01–0.99</sub>]<sub>10</sub>[(PO<sub>4</sub>, HPO<sub>4</sub>)<sub>5.27–5.68</sub>(CO<sub>3</sub>)<sub>0.32–0.73</sub>]<sub>6</sub>[(H<sub>2</sub>O,OH, Vac)<sub>1.11–1.61</sub>Cl<sub>0.39–0.89</sub>]<sub>2</sub>. The carbonate ion content is shown to increase from 2.03–1.72 to 5.54–3.56 wt % at a supersaturation of 50 or 100 and an increase in the experiment time from 2 weeks to 10. An increase in the experiment time to 12 weeks leads to a decrease in the carbonate ion content, and the maximum carbonate ion content (5.54 wt %) corresponds to the hydroxyapatite synthesized at a supersaturation of 50 and an experiment time of 10 weeks. The effect of the Verapamil drug on the resorption rate of the synthesized samples is found to be 2 times higher in a 0.9% NaCl solution and Tris buffer. Optical microscopy results obtained for the vascular Vitaflon implant detect intense calcium phosphates deposits covering an area of about 32.5%.</p>

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Modeling of the Crystallization of Calcium Phosphates from a Prototype of Human Blood Plasma

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • O. A. Golovanova

摘要

Abstract

Crystallization in solutions modeling the composition of human blood plasma has been studied as a function of the synthesis time and the solution supersaturation. XRD and IR spectroscopy demonstrate that the crystallized solid phases consist of carbonate hydroxyapatite. Nonstoichiometric water-containing carbonate hydroxyapatite with a small amount of chlorine, the composition of which coincides with human calcificate, forms during syntheses from a model human blood plasma solution. The generalized crystal formula of the synthesized samples is as follows: [Ca7.66–8.61Na0.59–1.24K0.11–0.34Mg0.08–0.31Vac0.01–0.99]10[(PO4, HPO4)5.27–5.68(CO3)0.32–0.73]6[(H2O,OH, Vac)1.11–1.61Cl0.39–0.89]2. The carbonate ion content is shown to increase from 2.03–1.72 to 5.54–3.56 wt % at a supersaturation of 50 or 100 and an increase in the experiment time from 2 weeks to 10. An increase in the experiment time to 12 weeks leads to a decrease in the carbonate ion content, and the maximum carbonate ion content (5.54 wt %) corresponds to the hydroxyapatite synthesized at a supersaturation of 50 and an experiment time of 10 weeks. The effect of the Verapamil drug on the resorption rate of the synthesized samples is found to be 2 times higher in a 0.9% NaCl solution and Tris buffer. Optical microscopy results obtained for the vascular Vitaflon implant detect intense calcium phosphates deposits covering an area of about 32.5%.