Scholarlink

Abstract <p>The paper presents the results of a study of the outflow of non-wetting liquids: distilled water (water) and 0.9% aqueous sodium chloride solution (saline) from hydrophobic nanoporous materials based on silica gels Fluka 100 C18 and Fluka 100 C8. The studies were carried out at waiting times of up to 10 000 s in a temperature range from 20 up to 60°C. It is shown that the specific rate of outflow of non-wetting liquids from these materials depends on the studied system, the characteristics of the material, the waiting time, the temperature and the degree of initial filling of the nanoporous material. The obtained results allow us to consider this type of nanoporous materials as promising for the delivery of prolonged-release drugs with controlled flow rate.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

On the Possibility of Using Nanoporous Materials Based on Silica Gels for Drug Delivery

  • 期刊论文

  • 发表日期：

    2025年2月1日

查看全文
  • A. A. Belogorlov,
  • S. A. Bortnikova,
  • A. G. Akopdzhanov,
  • N. L. Shimanovskii

摘要

Abstract

The paper presents the results of a study of the outflow of non-wetting liquids: distilled water (water) and 0.9% aqueous sodium chloride solution (saline) from hydrophobic nanoporous materials based on silica gels Fluka 100 C18 and Fluka 100 C8. The studies were carried out at waiting times of up to 10 000 s in a temperature range from 20 up to 60°C. It is shown that the specific rate of outflow of non-wetting liquids from these materials depends on the studied system, the characteristics of the material, the waiting time, the temperature and the degree of initial filling of the nanoporous material. The obtained results allow us to consider this type of nanoporous materials as promising for the delivery of prolonged-release drugs with controlled flow rate.