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Abstract <p>The results of the synthesis and study of new resorbable osteoinductive calcium silicophosphates doped with copper and zinc ions are presented. Using the high-temperature solid-phase synthesis method, compounds with glaserite-like structures such as nagelschmidtite and carnotite were obtained. It was established that the formation of single-phase copper-zinc-substituted silicophosphates requires synthesis at ~1500°C in an oxygen stream with preliminary calcination at 1000°C. Hydrolysis of the resulting compounds in aqueous solution provides a final pH of ~7.4–7.8, which meets physiological requirements. The solubility of these phases in a model solution of citric acid is significantly higher than that of traditional β-Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>, which classifies the new materials as highly resorbable. The resulting ceramics have a density of about 80% of the theoretical value with grain sizes of 2–3 µm. The development of Cu,Zn-containing silicophosphates expands the concept of multicomponent bioceramics and offers a promising material with controlled resorption properties and improved biological activity for use in regenerative medicine.</p>

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Phase Formation and Properties of Cu- and Zn-Doped Calcium Silicophosphates with a Glaserite-Type Structure

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • N. V. Leontiev,
  • A. A. Ryndzevich,
  • D. D. Pogolskaya,
  • D. S. Larionov,
  • D. O. Golubchikov,
  • Ya. Yu. Filippov,
  • E. S. Klimashina,
  • A. M. Murashko,
  • P. V. Evdokimov,
  • V. I. Putlayev

摘要

Abstract

The results of the synthesis and study of new resorbable osteoinductive calcium silicophosphates doped with copper and zinc ions are presented. Using the high-temperature solid-phase synthesis method, compounds with glaserite-like structures such as nagelschmidtite and carnotite were obtained. It was established that the formation of single-phase copper-zinc-substituted silicophosphates requires synthesis at ~1500°C in an oxygen stream with preliminary calcination at 1000°C. Hydrolysis of the resulting compounds in aqueous solution provides a final pH of ~7.4–7.8, which meets physiological requirements. The solubility of these phases in a model solution of citric acid is significantly higher than that of traditional β-Ca3(PO4)2, which classifies the new materials as highly resorbable. The resulting ceramics have a density of about 80% of the theoretical value with grain sizes of 2–3 µm. The development of Cu,Zn-containing silicophosphates expands the concept of multicomponent bioceramics and offers a promising material with controlled resorption properties and improved biological activity for use in regenerative medicine.