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Abstract <p>Developing an accessible method for determining methyl methacrylate (MMA) in aqueous media is an important task since it is necessary in dental practice to monitor the residual monomer released from denture material, polymethyl methacrylate (PMMA), into the oral cavity. The proposed electrophoretic method for determining MMA is characterized by high accuracy, short analysis time, and minimal sample preparation. Optimum analysis conditions were determined: surfactant concentration (sodium dodecyl sulfate, SDS) of 80 mmol/L, voltage applied to the capillary of 25 kV, and temperature of 25°C. The developed method was tested on real objects from dental practice: denture base materials intended for the fabrication and rebasing of prosthetic dental appliances. Monitoring of MMA release from PMMA samples allowed assessment of the residual monomer content in deionized water and a saliva-simulating fluid: the concentration of MMA in the model (saliva) solution was 35% lower than in water after 48 h. With direct spectrophotometric detection (λ = 215 nm), the limits of detection for MMA in deionized water and the saliva‑simulating fluid are 0.015 and 0.020 μg/mL, respectively.</p>

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Determination of Methyl Methacrylate in Aqueous Extracts of Polymethyl Methacrylate by Micellar Electrokinetic Chromatography

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • N. V. Mikhailova,
  • S. V. Stakhanova,
  • Yu. V. Ermolenko,
  • U. L. Kobets,
  • E. G. Vinokurov,
  • I. N. Semenova,
  • Ya. N. Kharakh

摘要

Abstract

Developing an accessible method for determining methyl methacrylate (MMA) in aqueous media is an important task since it is necessary in dental practice to monitor the residual monomer released from denture material, polymethyl methacrylate (PMMA), into the oral cavity. The proposed electrophoretic method for determining MMA is characterized by high accuracy, short analysis time, and minimal sample preparation. Optimum analysis conditions were determined: surfactant concentration (sodium dodecyl sulfate, SDS) of 80 mmol/L, voltage applied to the capillary of 25 kV, and temperature of 25°C. The developed method was tested on real objects from dental practice: denture base materials intended for the fabrication and rebasing of prosthetic dental appliances. Monitoring of MMA release from PMMA samples allowed assessment of the residual monomer content in deionized water and a saliva-simulating fluid: the concentration of MMA in the model (saliva) solution was 35% lower than in water after 48 h. With direct spectrophotometric detection (λ = 215 nm), the limits of detection for MMA in deionized water and the saliva‑simulating fluid are 0.015 and 0.020 μg/mL, respectively.