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Abstract <p>The oxidative degradation by interaction with hydroxyl and hydroperoxyl radicals and UV radiation at λ = 253.7 nm has been studied for bovine serum albumin; a mixture of the fluorescent amino acids tyrosine, tryptophan, and phenylalanine; and separately the same aromatic amino acids included in albumin. The starting materials and reaction products have been identified by fluorescence in the two-dimensional scanning mode. To analyze the results, Stern–Volmer fluorescence quenching constants have been calculated. The mechanisms of radical reactions and UV radiation-induced reactions with protein and individual amino acids are compared on the basis of the Stern–Volmer constants.</p>

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Degradation of Albumin and Aromatic Amino Acids in Reactions with OH• Radicals and under 253.7-nm UV Irradiation

  • 期刊论文

  • 发表日期：

    2025年9月14日

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  • I. M. Piskarev

摘要

Abstract

The oxidative degradation by interaction with hydroxyl and hydroperoxyl radicals and UV radiation at λ = 253.7 nm has been studied for bovine serum albumin; a mixture of the fluorescent amino acids tyrosine, tryptophan, and phenylalanine; and separately the same aromatic amino acids included in albumin. The starting materials and reaction products have been identified by fluorescence in the two-dimensional scanning mode. To analyze the results, Stern–Volmer fluorescence quenching constants have been calculated. The mechanisms of radical reactions and UV radiation-induced reactions with protein and individual amino acids are compared on the basis of the Stern–Volmer constants.