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Abstract <p>This study investigates the radioprotective effects of 2-deoxy-D-glucose-functionalized gold nanoparticles (2DG-AuNPs) using the comet assay. Gold nanoparticles were synthesized with different capping agents (2DG, citrate, and glucose). The DNA damage in human lymphocytes was assessed using single-cell gel electrophoresis (comet assay) before and after exposure to 8 MeV electron beam radiation. Results showed minimal DNA damage with 2DG-AuNPs and glucose-capped AuNPs, while citrate-capped AuNPs exhibited toxic effects on lymphocytes. The study concludes that 2DG-AuNPs demonstrate radioprotective effects in lymphocytes, suggesting potential applications in radiotherapy. This research contributes to the safe use of gold nanoparticles in biomedical applications and highlights the importance of capping agents in determining their biological effects.</p>

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Assessment of Radioprotective Effects of 2-Deoxy-D-Glucose-Functionalized Gold Nanoparticles Using Comet Assay

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • Saritha Suvarna,
  • Sunil KC,
  • Rajesha Nairy,
  • Narasimha Raghavendra,
  • Narayana Yerol

摘要

Abstract

This study investigates the radioprotective effects of 2-deoxy-D-glucose-functionalized gold nanoparticles (2DG-AuNPs) using the comet assay. Gold nanoparticles were synthesized with different capping agents (2DG, citrate, and glucose). The DNA damage in human lymphocytes was assessed using single-cell gel electrophoresis (comet assay) before and after exposure to 8 MeV electron beam radiation. Results showed minimal DNA damage with 2DG-AuNPs and glucose-capped AuNPs, while citrate-capped AuNPs exhibited toxic effects on lymphocytes. The study concludes that 2DG-AuNPs demonstrate radioprotective effects in lymphocytes, suggesting potential applications in radiotherapy. This research contributes to the safe use of gold nanoparticles in biomedical applications and highlights the importance of capping agents in determining their biological effects.