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Abstract <p>Biological reducing agents have become increasingly significant due to their ability to reduce the impact of toxic chemicals in nanoparticle synthesis. This study presents a green method for synthesizing zinc oxide nanoparticles (ZnO-NPs) using an aqueous leaf extract of <i>Setaria verticillata</i> as a bioreductant. The synthesized ZnO-NPs were characterized through various techniques, including UV-Vis Spectroscopy (UV-Vis), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX), Fourier Transform Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), and Transmission Electron Microscopy (TEM). UV-Vis spectroscopy confirmed the formation of ZnO-NPs, while SEM analysis revealed that the biosynthesized nanoparticles has wurtzite hexagonal structure with particle size ranging from 20 to 200 nm. In vitro cytotoxicity studies using the trypan blue assay against Dalton’s lymphoma ascites (DLA) cell lines showed a 71% inhibition at a concentration of 200 µg/mL. Furthermore, photocatalytic degradation experiments on the antibiotic ciprofloxacin demonstrated complete degradation within 25 min of exposure to visible light.</p>

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Biocompatible Zinc Oxide Nanoparticles Synthesized via Green Pathways: a New Horizon for Antibiotic Degradation and Cancer Treatment

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • K. Kanagamani,
  • G. Abhishek,
  • D. Adhishkannan,
  • M. Sakthivel,
  • P. Muthukrishnan

摘要

Abstract

Biological reducing agents have become increasingly significant due to their ability to reduce the impact of toxic chemicals in nanoparticle synthesis. This study presents a green method for synthesizing zinc oxide nanoparticles (ZnO-NPs) using an aqueous leaf extract of Setaria verticillata as a bioreductant. The synthesized ZnO-NPs were characterized through various techniques, including UV-Vis Spectroscopy (UV-Vis), Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX), Fourier Transform Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), and Transmission Electron Microscopy (TEM). UV-Vis spectroscopy confirmed the formation of ZnO-NPs, while SEM analysis revealed that the biosynthesized nanoparticles has wurtzite hexagonal structure with particle size ranging from 20 to 200 nm. In vitro cytotoxicity studies using the trypan blue assay against Dalton’s lymphoma ascites (DLA) cell lines showed a 71% inhibition at a concentration of 200 µg/mL. Furthermore, photocatalytic degradation experiments on the antibiotic ciprofloxacin demonstrated complete degradation within 25 min of exposure to visible light.