Scholarlink

Abstract <p>Cell malignant transformation is accompanied by a remodeling of various cell life-support systems, including calcium signaling. Modulation of the calcium signal can significantly sensitize cancer cells, making them more sensitive to anticancer drugs. A search for selective compounds that influence the cell calcium response is a promising area in the development of combination therapies for oncology diseases. The aim of this study was to determine the effect of 4-MPTC on the invasive potential of triple-negative breast cancer cells. 4-MPTC was previously selected as a modulator of the Stim2-dependent calcium entry pathway via a small molecule screening. 4-MPTC was shown to induce a massive calcium release from the intracellular calcium store in the endoplasmic reticulum (ER), blocks store-operated calcium entry, and reduces proliferation and migration activity of MDA-MB-468 triple-negative breast cancer cells.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Calcium Signaling Modulator 4-MPTC Reduces Proliferative and Migration Activities of MDA-MB-468 Breast Cancer Cells

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月1日

查看全文
  • A. Yu. Skopin,
  • K. O. Gusev,
  • D. A. Grekhnev,
  • L. N. Glushankova,
  • V. G. Kartsev,
  • E. V. Kaznacheyeva

摘要

Abstract

Cell malignant transformation is accompanied by a remodeling of various cell life-support systems, including calcium signaling. Modulation of the calcium signal can significantly sensitize cancer cells, making them more sensitive to anticancer drugs. A search for selective compounds that influence the cell calcium response is a promising area in the development of combination therapies for oncology diseases. The aim of this study was to determine the effect of 4-MPTC on the invasive potential of triple-negative breast cancer cells. 4-MPTC was previously selected as a modulator of the Stim2-dependent calcium entry pathway via a small molecule screening. 4-MPTC was shown to induce a massive calcium release from the intracellular calcium store in the endoplasmic reticulum (ER), blocks store-operated calcium entry, and reduces proliferation and migration activity of MDA-MB-468 triple-negative breast cancer cells.