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Abstract <p>The effect of endogenous quaternary ammonium compounds, derivatives of choline, acetylcholine, and L-carnitine, on the decomposition of hydroperoxides has been studied. It has been established that choline and acetylcholine in organic media form joint nanoaggregates {QAC–ROOH}, in which the radical decomposition of hydroperoxides is accelerated; choline and acetylcholine immobilized on a solid carrier (microcrystalline cellulose) retain the ability to generate radicals in the presence of hydroperoxides and initiate chain processes of oxidation and radical polymerization. L-Carnitine, unlike acetylcholine and choline, is an internal salt, and the R<sub>4</sub>N<sup>+</sup> cation is neutralized by the carboxyl group –<InlineEquation ID="IEq1"> <EquationSource Format="TEX">\({\text{CO}}_{2}^{ - }\)</EquationSource> <!--BioPhys2570099Krugovov-m1--> </InlineEquation>, that is, L-carnitine does not have an external counterion and, probably for this reason, differs from acetylcholine and choline in the mechanisms of adsorption and interaction with hydroperoxides. Individual L-carnitine does not affect lipid oxidation processes, but in combination with 2-ethyl-6-methyl-3-hydroxypyridine forms 2-ethyl-6-methyl-3-hydroxypyridinium carnitinate , which has antioxidant and biological activity. In this work, choline, L-carnitine, and 2-ethyl-6-methyl-3-hydroxypyridinium carnitinate are compared in terms of growth-stimulating activity using the example of wheat seed germination.</p>

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Pro- and Antioxidant Properties of Compositions Based on Endogenous Choline Derivatives

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • D. A. Krugovov,
  • I. F. Rusina,
  • N. V. Zakhvatova,
  • Yu. N. Egorova,
  • L. A. Smurova,
  • V. V. Vedutenko,
  • V. G. Kondratovich,
  • M. P. Berezin,
  • O. T. Kasaikina

摘要

Abstract

The effect of endogenous quaternary ammonium compounds, derivatives of choline, acetylcholine, and L-carnitine, on the decomposition of hydroperoxides has been studied. It has been established that choline and acetylcholine in organic media form joint nanoaggregates {QAC–ROOH}, in which the radical decomposition of hydroperoxides is accelerated; choline and acetylcholine immobilized on a solid carrier (microcrystalline cellulose) retain the ability to generate radicals in the presence of hydroperoxides and initiate chain processes of oxidation and radical polymerization. L-Carnitine, unlike acetylcholine and choline, is an internal salt, and the R4N+ cation is neutralized by the carboxyl group – \({\text{CO}}_{2}^{ - }\) , that is, L-carnitine does not have an external counterion and, probably for this reason, differs from acetylcholine and choline in the mechanisms of adsorption and interaction with hydroperoxides. Individual L-carnitine does not affect lipid oxidation processes, but in combination with 2-ethyl-6-methyl-3-hydroxypyridine forms 2-ethyl-6-methyl-3-hydroxypyridinium carnitinate , which has antioxidant and biological activity. In this work, choline, L-carnitine, and 2-ethyl-6-methyl-3-hydroxypyridinium carnitinate are compared in terms of growth-stimulating activity using the example of wheat seed germination.