<p>The results of using differential heart rate monitoring for noninvasive screening and analysis of the functional state of the cardiovascular system and the nature of its autonomous regulation in patients with metabolic syndrome are presented. The indicators characterizing the general cardiohemodynamics, as well as the variability of the <i>V</i>_maxPP and PP parameters of cyclic waves of blood pulse pressure, reflecting the regulatory effect of peripheral mechanisms of the autonomic nervous system and the endocrine system on the cardiovascular system of patients with metabolic syndrome, are evaluated. The involvement and role of myocytes of the wall of the left ventricle of the heart as a universal muscle effector providing both the main pumping function of the cardiovascular system and the possibility of regulating the strength and speed of contractions of the left ventricle of the heart is considered. The prognostic significance of a comprehensive piezopulsometric examination of the cardiovascular system of patients for early noninvasive detection of signs of metabolic syndrome and its treatment is discussed.</p>