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<p>The effect of 30-day antiorthostatic hanging of male <i>Mus musculus</i> mice on spermogram parameters, including the use of essential phospholipids, was studied. The concentration and motility of spermatozoa were measured and the fertilizing ability, the content of cholesterol, calcium ions and cytoskeletal proteins in spermatozoa were assessed. To assess the specificity of changes in spermatozoa, the contents of cholesterol and cytoskeletal proteins were determined using buccal epithelial cells. It was shown that anti-orthostatic hanging led to a decrease in the proportion of fertilized oocytes and the absence of 2–4-cell embryos, but the use of essential phospholipids prevented these changes. The observed increase in the cholesterol content in spermatozoa, which is nonspecific due to similar changes in buccal epithelial cells, in response to anti-orthostatic hanging, as well as the accumulation of calcium ions, could change the effectiveness of capacitation and cause a decrease in fertilizing capacity, which requires further research.</p>

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The Effect of Antiorthostatic Suspension on Sperm Parameters of Mus musculus Mice

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • K. K. Gogichaeva,
  • R. V. Serebryakova,
  • D. I. Fomina,
  • Yu. S. Zhdankina,
  • N. S. Biryukov,
  • O. V. Kotov,
  • I. V. Ogneva

摘要

The effect of 30-day antiorthostatic hanging of male Mus musculus mice on spermogram parameters, including the use of essential phospholipids, was studied. The concentration and motility of spermatozoa were measured and the fertilizing ability, the content of cholesterol, calcium ions and cytoskeletal proteins in spermatozoa were assessed. To assess the specificity of changes in spermatozoa, the contents of cholesterol and cytoskeletal proteins were determined using buccal epithelial cells. It was shown that anti-orthostatic hanging led to a decrease in the proportion of fertilized oocytes and the absence of 2–4-cell embryos, but the use of essential phospholipids prevented these changes. The observed increase in the cholesterol content in spermatozoa, which is nonspecific due to similar changes in buccal epithelial cells, in response to anti-orthostatic hanging, as well as the accumulation of calcium ions, could change the effectiveness of capacitation and cause a decrease in fertilizing capacity, which requires further research.