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<p>New data have been obtained that expand the understanding of the role of the chemical structure and physico-chemical properties of photosensitizer molecules in determining the processes of their interaction with various biological objects, including serum proteins, biological membranes, cells and cellular systems. Changes in the side substituents in the chlorin <i>e</i><sub>6</sub> molecule significantly affect the physico-chemical properties of new compounds, the level of their accumulation in cells, and the rate of migration between cells, but do not significantly affect the intracellular localization of sensitizers. It is assumed that the increased photosensitizing activity of chlorin <i>e</i><sub>6</sub> derivatives is due to the effect of lateral substituents on their biodistribution processes.</p>

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Comparative Analysis of Sensitizing Activity and Biodistribution Characteristics of Chlorin e6 Derivatives: Effect of the Nature of Charged Groups

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • T. E. Zorina,
  • T. I. Ermilova,
  • I. V. Kablov,
  • I. E. Kravchenko,
  • T. V. Shman,
  • T. V. Kustova,
  • D. B. Berezin,
  • I. S. Khudyaeva,
  • V. P. Zorin

摘要

New data have been obtained that expand the understanding of the role of the chemical structure and physico-chemical properties of photosensitizer molecules in determining the processes of their interaction with various biological objects, including serum proteins, biological membranes, cells and cellular systems. Changes in the side substituents in the chlorin e6 molecule significantly affect the physico-chemical properties of new compounds, the level of their accumulation in cells, and the rate of migration between cells, but do not significantly affect the intracellular localization of sensitizers. It is assumed that the increased photosensitizing activity of chlorin e6 derivatives is due to the effect of lateral substituents on their biodistribution processes.