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<b>Abstract</b> <p>The aim of this work was to evaluate the effects of gel materials containing taxifoline pentaglutarate and a conjugate of taxifolin with glyoxylic acid on the healing of skin wounds caused by acetic acid. It was shown that collagen materials containing polyphenols accelerated re-epithelialization and formation of granulation tissue compared with the control (collagen alone). The data obtained indicate that taxifolin derivatives can be considered as promising agents that not only cross-link collagen molecules, but also have a wound-healing effect. In turn, materials based on collagen and these polyphenols can be considered as dual purpose materials, that is, as wound-healing agents and as a delivery system of biologically active substances to the area of injury.</p>

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The Effect of Gel Materials Based on Collagen and Taxifolin Derivatives on the Healing of Burn Wounds Induced by Acetic Acid

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • Yu. V. Shatalin,
  • V. S. Shubina

摘要

Abstract

The aim of this work was to evaluate the effects of gel materials containing taxifoline pentaglutarate and a conjugate of taxifolin with glyoxylic acid on the healing of skin wounds caused by acetic acid. It was shown that collagen materials containing polyphenols accelerated re-epithelialization and formation of granulation tissue compared with the control (collagen alone). The data obtained indicate that taxifolin derivatives can be considered as promising agents that not only cross-link collagen molecules, but also have a wound-healing effect. In turn, materials based on collagen and these polyphenols can be considered as dual purpose materials, that is, as wound-healing agents and as a delivery system of biologically active substances to the area of injury.