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Abstract <p>Intracellular accumulation of chemotherapeutic drugs in resistant cells of acute myeloid leukemia cultured in a three-dimensional high-density culture was studied. It was shown that neither the dense arrangement of cells nor the presence of the main ABC family transporter proteins most likely affects the increase in drug resistance of acute myeloid leukemia cells in a three-dimensional high-density cell culture. These data indicate the involvement of other mechanisms in increasing drug resistance in three-dimensional high-density cell cultures of acute myeloid leukemia.</p>

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The Mechanisms of Drug Resistance of Acute Myeloid Leukemia Cells in Three-Dimensional High-Density Cultures: a Study of Intracellular Accumulation of Chemotherapeutic Drugs

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • M. I. Kobyakova,
  • Ya. V. Lomovskaya,
  • R. S. Fadeev

摘要

Abstract

Intracellular accumulation of chemotherapeutic drugs in resistant cells of acute myeloid leukemia cultured in a three-dimensional high-density culture was studied. It was shown that neither the dense arrangement of cells nor the presence of the main ABC family transporter proteins most likely affects the increase in drug resistance of acute myeloid leukemia cells in a three-dimensional high-density cell culture. These data indicate the involvement of other mechanisms in increasing drug resistance in three-dimensional high-density cell cultures of acute myeloid leukemia.