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<b>Abstract</b> <p>The effect of the Thr–Ser–Lys–Tyr peptide isolated from the brain of the obligate hibernating long-tailed ground squirrel Urocitellus undulatus (formerly Citellus undulatus, Spermophilus undulatus) on the polymerization/depolymerization of actin in vitro was studied by electron microscopy. Upon incubation of the peptide with globular (monomeric) actin at concentrations of 0.1 mg/mL (at a ratio of 1&#xa0;:&#xa0;1), the formation of single filaments of actin was observed. When the peptide was added to the formed actin filaments, no effects were observed, in particular, actin depolymerization. The possible involvement of the peptide in the polymerization of actin in vivo and a possible contribution to the restoration of the functional activity of the central nervous system after the hibernating animal leaves the state of hypothermia are discussed.</p>

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The Effect of the Thr–Ser–Lys–Tyr Peptide on Actin Polymerization in vitro

  • 期刊论文

  • 发表日期：

    2025年8月1日

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  • G. Z. Mikhailova,
  • L. G. Bobyleva,
  • A. G. Bobylev,
  • T. A. Uryupina,
  • S. N. Udaltsov,
  • R. H. Ziganshin,
  • L. I. Kramarova,
  • I. M. Vikhlyantsev

摘要

Abstract

The effect of the Thr–Ser–Lys–Tyr peptide isolated from the brain of the obligate hibernating long-tailed ground squirrel Urocitellus undulatus (formerly Citellus undulatus, Spermophilus undulatus) on the polymerization/depolymerization of actin in vitro was studied by electron microscopy. Upon incubation of the peptide with globular (monomeric) actin at concentrations of 0.1 mg/mL (at a ratio of 1 : 1), the formation of single filaments of actin was observed. When the peptide was added to the formed actin filaments, no effects were observed, in particular, actin depolymerization. The possible involvement of the peptide in the polymerization of actin in vivo and a possible contribution to the restoration of the functional activity of the central nervous system after the hibernating animal leaves the state of hypothermia are discussed.