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<p>Using methods of general and biochemical blood analysis and histological analysis of the lungs, liver, heart and kidneys of Syrian hamsters, it was determined whether aerosol treatment of these animals with binuclear dinitrosyl iron complexes with glutathione, alone or followed by similar treatment of the same animals with diethyldithiocarbamate, as well as aerosol treatment of Syrian hamsters with dinitrosyl iron complexes with mercaptosuccinate, leads to negative toxic effects at the level of the whole organism. The detected weak reversible toxic effect in the form of nephrotoxicity of such treatment allows us to assert that such an effect, which suppresses of covid infection in these animals, is due to the selective in vivo action of dinitrosyl iron complexes and diethyldithiocarbamate on the SARS-CoV-2 virus, without affecting other tissues and organs of the animal.</p>

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The Mild Toxic Effect of Dinitrosyl Iron Complexes during Inhalation of Syrian Hamsters in a “Nose-Only” Chamber

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • S. V. Ankov,
  • A. V. Shipovalov,
  • K. S. Bogatischeva,
  • N. A. Zhukova,
  • A. F. Vanin,
  • N. A. Tkachev,
  • O. V. Pyankov,
  • N. B. Asanbaeva,
  • E. G. Bagryanskaya

摘要

Using methods of general and biochemical blood analysis and histological analysis of the lungs, liver, heart and kidneys of Syrian hamsters, it was determined whether aerosol treatment of these animals with binuclear dinitrosyl iron complexes with glutathione, alone or followed by similar treatment of the same animals with diethyldithiocarbamate, as well as aerosol treatment of Syrian hamsters with dinitrosyl iron complexes with mercaptosuccinate, leads to negative toxic effects at the level of the whole organism. The detected weak reversible toxic effect in the form of nephrotoxicity of such treatment allows us to assert that such an effect, which suppresses of covid infection in these animals, is due to the selective in vivo action of dinitrosyl iron complexes and diethyldithiocarbamate on the SARS-CoV-2 virus, without affecting other tissues and organs of the animal.