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<p>Bacteriophage endolysins are part of a complex of lytic enzymes responsible for the destruction of peptidoglycan in the bacterial cell wall. The dynamic features of single-domain endolysin of bacteriophage T5 and multi-domain endolysin PlyG of gamma phage have been studied by methods of molecular dynamics and normal mode analysis. The nature of activation of bacteriophage T5 endolysins by calcium and a discovered fundamental difference in the dynamic features of single-domain and multi-domain endolysins are explained.</p>

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Comparative Analysis of Dynamic Features of Endolysins T5 and PlyG In Silico

  • 期刊论文

  • 发表日期：

    2025年4月1日

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  • A. G. Arakelian,
  • G. N. Chuev,
  • T. V. Mamedov,
  • A. Arikov,
  • K. R. Ismailov

摘要

Bacteriophage endolysins are part of a complex of lytic enzymes responsible for the destruction of peptidoglycan in the bacterial cell wall. The dynamic features of single-domain endolysin of bacteriophage T5 and multi-domain endolysin PlyG of gamma phage have been studied by methods of molecular dynamics and normal mode analysis. The nature of activation of bacteriophage T5 endolysins by calcium and a discovered fundamental difference in the dynamic features of single-domain and multi-domain endolysins are explained.