<p>Currently, isometric exercises are widely used to increase muscle strength and endurance. They are also used in rehabilitation protocols for people with limited joint mobility after arthroplasty operations. The paper considers the effect of isometric exercises on the morpho-functional characteristics of muscle cells, cytokine secretion by muscle cells, blood circulation and mass transfer in muscle tissue, as well as on bone remodeling and repair. The existing protocols for early rehabilitation of patients after arthroplasty are not optimal and do not take into account the individual characteristics of patients. To develop effective methods of early rehabilitation of patients after arthroplasty, it is necessary to know the biophysical basis of the influence of isometric exercises on the regeneration of muscle and bone tissue.</p>