<p>The dynamics of hamsters’ motor activity was compared with the number of strong earthquakes with a magnitude ≥4.5. A positive correlation was found between the total daily motor activity calculated for the period from 6 p.m. on the previous day to 6 p.m. on the current day and the global seismic activity of the current day (<i>r</i> = 0.34, <i>p</i> = 0.02). Numerous local aftershocks do not affect the biological indicator under study. The data obtained indicate that it is not the effects of earthquakes on the geosphere that affect animals, but global seismic activity that is only a marker of the desired biotropic factor. Moreover, a long-term two-center study (Moscow and Ulyanovsk) established a positive correlation (<i>r</i> = 0.42, <i>p</i> = 0.003) between the intensity of oscillations in the counting rate from the natural isotope potassium-40 and the level of global seismicity (excluding aftershocks). Taking into account the previously identified relationship between oscillations in the counting rate from ⁴⁰K and biological parameters, this fact indicates the existence of some general influence on animal activity, radioactive decay and global seismicity.</p>