<p>The effect of astaxanthin, diethyldithiocarbamate and their combined use on cell proliferation was studied on the culture of mouse N1E-115 neuroblastoma (clone C-1300). There is evidence of the anticancer effect of astaxanthin in various types of tumor cells. Diethyldithiocarbamates are used as additional drugs in chemotherapy. The use of non-toxic drug complexes is a new strategy for the treatment of oncological diseases. We have shown that the effect of diethyldithiocarbamate and astaxanthin, both individually and when used together, caused inhibition of proliferation and induction of differentiation of mouse N1E-115 neuroblastoma cells. Western blot analysis revealed that the combination of the drugs increased the expression of CHOP protein (a marker of the endoplasmic reticulum) and proapoptotic protein BAX, and reduced the expression of antiapoptotic protein Bcl-2, which may indicate the start of the apoptotic cascade. At the same time, the use of diethyldithiocarbamate alone caused a decrease in both Bax and Bcl-2 levels and did not affect CHOP protein expression. Apparently, astaxanthin modifies the effect of diethyldithiocarbamate when they are used together.</p>