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<p>Bioactive polylactide fibers containing 6 wt % of iodine and characterized by high mechanical properties, an elastic modulus of about 3 GPa and a strength of 125 MPa, were obtained using the liquid crazing methodology. It was shown that iodine in such materials is uniformly distributed throughout the polymer volume and forms nanoparticles 5–15 nm in size. It was found that the process of destruction of iodine-containing polylactide fibers in a model medium with a phosphate-buffered saline at 37°C occurs quite quickly, in 6 weeks, the molecular mass of the polymer decreases almost an order of magnitude to 9.4 kDa, and the dispersion increases to 5.5. Under <i>in vivo</i> conditions, in the presence of iodine-containing fibers, the inflammatory reaction phase is suppressed and muscle tissue hypertrophy is stimulated.</p>

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Fabrication and Properties of Iodine-Containing Polylactide Fibers

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • E. S. Trofimchuk,
  • M. A. Khavpachev,
  • A. A. Temnov,
  • A. A. Puchkov,
  • N. G. Sedush,
  • M. A. Moskvina,
  • N. I. Nikonorova,
  • S. N. Chvalun

摘要

Bioactive polylactide fibers containing 6 wt % of iodine and characterized by high mechanical properties, an elastic modulus of about 3 GPa and a strength of 125 MPa, were obtained using the liquid crazing methodology. It was shown that iodine in such materials is uniformly distributed throughout the polymer volume and forms nanoparticles 5–15 nm in size. It was found that the process of destruction of iodine-containing polylactide fibers in a model medium with a phosphate-buffered saline at 37°C occurs quite quickly, in 6 weeks, the molecular mass of the polymer decreases almost an order of magnitude to 9.4 kDa, and the dispersion increases to 5.5. Under in vivo conditions, in the presence of iodine-containing fibers, the inflammatory reaction phase is suppressed and muscle tissue hypertrophy is stimulated.