The Radioprotective Effect of Exogenous Peroxiredoxin 6 in Mice Exposed to Different Doses of Whole-Body Ionizing Radiation

The search for effective and safe radio-modulating compounds that reduce cancer cell radioresistance and/or the concomitant damage to normal tissues caused by radiation remains a significant challenge in radiation therapy. Peroxiredoxin 6, a member of the thiol-specific peroxidase family, is a promising candidate to solve this problem. However, often in studies, insufficient attention is paid to radiation parameters and there is no information about how different radiation parameters influence the radioprotective effect of exogenous peroxiredoxin 6. This article shows the peculiarities of the radioprotective effects of intravenous peroxiredoxin 6 at a concentration of 20 μg/g body weight and its mutant form Prx6-C47S (without peroxidase activity) administered shortly before X-ray or γ-irradiation with different dose rates and exposure times. Survival rates of the 10 Gy γ-irradiation 0.125 Gy/min and 7 Gy X-ray irradiation 1 Gy/min animal groups (an 8-fold difference in dose rate and exposure time) were correlated both for control and experimental animals.