The Nature of Intermolecular Interactions Affecting Oligomerization of Nt.BspD6I Nickase
摘要
Knowledge of the nature of intermolecular interactions and the amino-acid residues that provide them makes it possible to purposefully change the stability of intermolecular complexes. This study, using nickase Nt.BspD6I as an example, demonstrated the effect of hydrophobic interactions on a protein’s ability to oligomerize and the need for chemical and geometric complementarity of interface surfaces in the formation of stable homocomplexes.