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Abstract <p>Long non-coding RNAs (lncRNAs) are a novel class of regulators of key cellular processes and biomarkers of various pathologies. The lncRNA <i>JPX</i> is a multifunctional RNA involved in the regulation of transcription, translation, and chromatin architecture. <i>JPX</i> influences transcription and enhancer-promoter communication by regulating binding of proteins to DNA, particularly by interacting with the chromatin architectural protein CTCF. Additionally, <i>JPX</i> can interact with microRNAs, repressor proteins, or mRNA stabilizers, regulating translation in pathogenesis of oncological and other diseases. This review summarizes the accumulated knowledge about the structure, evolutionary origin, and functions of the long non-coding RNA <i>JPX</i> in normal and pathological conditions.</p>

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Long Non-Coding RNA JPX: Structure, Functions, and Role in Chromatin Architecture

  • 期刊论文

  • 发表日期：

    2025年11月1日

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  • Arseniy V. Selivanovskiy,
  • Anastasiia L. Sivkina,
  • Sergei V. Ulianov,
  • Sergei V. Razin

摘要

Abstract

Long non-coding RNAs (lncRNAs) are a novel class of regulators of key cellular processes and biomarkers of various pathologies. The lncRNA JPX is a multifunctional RNA involved in the regulation of transcription, translation, and chromatin architecture. JPX influences transcription and enhancer-promoter communication by regulating binding of proteins to DNA, particularly by interacting with the chromatin architectural protein CTCF. Additionally, JPX can interact with microRNAs, repressor proteins, or mRNA stabilizers, regulating translation in pathogenesis of oncological and other diseases. This review summarizes the accumulated knowledge about the structure, evolutionary origin, and functions of the long non-coding RNA JPX in normal and pathological conditions.