Scholarlink

Abstract <p>In this review, we analyze diversity of mitochondrial uncouplers, a class of compounds, which was in the focus of Vladimir Skulachev’s attention throughout his scientific career, starting from the basics of bioenergetics and validation of Mitchell’s chemiosmotic theory to the development of concepts of mild uncoupling and its therapeutic role. The review is the first to put forward the idea of classifying uncouplers by the type of a functional group that provides their protonophoric activity, i.e., the ability to transfer protons across the membrane, causing its depolarization and thereby uncoupling the ATP synthesis from the operation of proton pumps in the electron transport chain. In particular, it is shown that anionic and zwitterionic uncouplers can be divided into groups of OH-, NH-, SH-, and CH-acids. Of importance, here we consider metabolic transformations of mitochondrial uncouplers determining tissue-specificity of their action.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Classification of Mitochondrial Protonophoric Uncouplers and their Modifications in Biological Environment

  • 期刊论文

  • 发表日期：

    2025年12月23日

查看全文
  • Yuri N. Antonenko,
  • Elena A. Kotova,
  • Vladimir S. Krasnov,
  • Roman S. Kirsanov

摘要

Abstract

In this review, we analyze diversity of mitochondrial uncouplers, a class of compounds, which was in the focus of Vladimir Skulachev’s attention throughout his scientific career, starting from the basics of bioenergetics and validation of Mitchell’s chemiosmotic theory to the development of concepts of mild uncoupling and its therapeutic role. The review is the first to put forward the idea of classifying uncouplers by the type of a functional group that provides their protonophoric activity, i.e., the ability to transfer protons across the membrane, causing its depolarization and thereby uncoupling the ATP synthesis from the operation of proton pumps in the electron transport chain. In particular, it is shown that anionic and zwitterionic uncouplers can be divided into groups of OH-, NH-, SH-, and CH-acids. Of importance, here we consider metabolic transformations of mitochondrial uncouplers determining tissue-specificity of their action.