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Abstract <p>It is difficult to predict the process of occurrence of an epileptogenic focus in patients who have suffered acute cerebral damage. The aim of our study is to investigate and describe the possibility of using microRNAs as biomarkers of epileptogenesis. Objective of our work was to evaluate expression of hsa-miR-134-5p, hsa-miR-155-5p, and has-miR-122-5p in different groups of patients. Quantitative comparison of relative concentrations of the studied microRNAs in the blood plasma of three groups of patients was carried out: Group&#xa0;I&#xa0;– patients with temporal lobe epilepsy; Group II – patients with potential epileptogenic injuries; Group III&#xa0;– control group. The study showed increased expression of hsa-miR-134-5p in patients with temporal lobe epilepsy, which confirms the published data on its involvement in the mechanisms of epileptogenesis. Hsa-miR-155-5p was overexpressed in the Group II in comparison with other groups, the data indicate involvement in the mechanisms of inflammation, which could indirectly affect occurrence of epilepsy. Hsa-miR-122-5p was overexpressed in two study groups, but the levels were higher in the group of patients with acute cerebral injuries. The obtained results allow us to propose has-miR-122-5p as a potential biomarker of epileptogenesis.</p>

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Differential Expression of hsa-miR-134, hsa-miR-155, hsa-miR-122 as Biomarkers of Epileptogenesis in Patients with Acute Cerebral Injury

  • 期刊论文

  • 发表日期：

    2025年2月1日

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  • Anastasia A. Vasilieva,
  • Elena E. Timechko,
  • Anastasia I. Paramonova,
  • Alexey M. Yakimov,
  • Kristina D. Lysova,
  • Marina I.Severina,
  • Diana V. Dmitrenko

摘要

Abstract

It is difficult to predict the process of occurrence of an epileptogenic focus in patients who have suffered acute cerebral damage. The aim of our study is to investigate and describe the possibility of using microRNAs as biomarkers of epileptogenesis. Objective of our work was to evaluate expression of hsa-miR-134-5p, hsa-miR-155-5p, and has-miR-122-5p in different groups of patients. Quantitative comparison of relative concentrations of the studied microRNAs in the blood plasma of three groups of patients was carried out: Group I – patients with temporal lobe epilepsy; Group II – patients with potential epileptogenic injuries; Group III – control group. The study showed increased expression of hsa-miR-134-5p in patients with temporal lobe epilepsy, which confirms the published data on its involvement in the mechanisms of epileptogenesis. Hsa-miR-155-5p was overexpressed in the Group II in comparison with other groups, the data indicate involvement in the mechanisms of inflammation, which could indirectly affect occurrence of epilepsy. Hsa-miR-122-5p was overexpressed in two study groups, but the levels were higher in the group of patients with acute cerebral injuries. The obtained results allow us to propose has-miR-122-5p as a potential biomarker of epileptogenesis.