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Abstract <p>It was found out that when the patients with atherosclerosis are orally administered ubiquinone Q<sub>10</sub> (CoQ<sub>10</sub>), oxidation (lipid hydroperoxide content) of the low-density lipoprotein (LDL) particles sharply decreases, which confirms important role of this natural antioxidant in protecting LDL particles from free radical oxidation <i>in&#xa0;vivo</i>. Influence of the lipophilic natural antioxidants ubiquinol Q<sub>10</sub> (CoQ<sub>10</sub>H<sub>2</sub>) and α-tocopherol (α-TOH) on the kinetic parameters of Cu<sup>2+</sup>-induced free radical oxidation of LDL particles was investigated. In this model system, possible synergism of the antioxidant action of CoQ<sub>10</sub>H<sub>2</sub> and α-TOH has been shown. Putative mechanisms of bioregeneration of lipophilic antioxidants in LDL particles, including regeneration of α-TOH from the tocopheroxyl radical (α-TO<sup>•</sup>) with participation of CoQ<sub>10</sub>H<sub>2</sub> and/or ascorbate, are discussed.</p>

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Mechanisms of Antioxidant Protection of Low-Density Lipoprotein Particles Against Free Radical Oxidation

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • Vadim Z. Lankin,
  • Konstantin B. Shumaev,
  • Valeria A. Medvedeva,
  • Alla K. Tikhaze,
  • Galina G. Konovalova

摘要

Abstract

It was found out that when the patients with atherosclerosis are orally administered ubiquinone Q10 (CoQ10), oxidation (lipid hydroperoxide content) of the low-density lipoprotein (LDL) particles sharply decreases, which confirms important role of this natural antioxidant in protecting LDL particles from free radical oxidation in vivo. Influence of the lipophilic natural antioxidants ubiquinol Q10 (CoQ10H2) and α-tocopherol (α-TOH) on the kinetic parameters of Cu2+-induced free radical oxidation of LDL particles was investigated. In this model system, possible synergism of the antioxidant action of CoQ10H2 and α-TOH has been shown. Putative mechanisms of bioregeneration of lipophilic antioxidants in LDL particles, including regeneration of α-TOH from the tocopheroxyl radical (α-TO•) with participation of CoQ10H2 and/or ascorbate, are discussed.