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Abstract <p>SARS-CoV-2 utilizes host cell RNA-binding proteins (RBPs) to carry out many steps of the infectious cycle. At the same time, a number of human RBPs are involved in antiviral immunity. During circulation in the human population, mutations that appeared in the SARS-CoV-2 genome could alter the interaction between cellular RBPs and the virus. Here, we have analyzed the genomes of various SARS-CoV-2 strains, including the Alpha, Delta and Omicron variants, and proposed a model of interactions between RBPs and SARS-CoV-2 RNA. It turned out that, despite the generally accepted opinion about the importance of the RBP‒virus interaction, since the onset of the COVID-19 pandemic there has been a gradual decrease in the affinity of RBPs for SARS-CoV-2 RNA.</p>

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During SARS-CoV-2 Evolution, the Interaction between Virus RNA and Host RNA-Binding Proteins Gradually Weakened

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • K. E. Malkova,
  • A. P. Zhiyanov,
  • A. V. Belaya,
  • A. V. Arzumanova,
  • I. D. Kirillov,
  • S. A. Tonevitskaya

摘要

Abstract

SARS-CoV-2 utilizes host cell RNA-binding proteins (RBPs) to carry out many steps of the infectious cycle. At the same time, a number of human RBPs are involved in antiviral immunity. During circulation in the human population, mutations that appeared in the SARS-CoV-2 genome could alter the interaction between cellular RBPs and the virus. Here, we have analyzed the genomes of various SARS-CoV-2 strains, including the Alpha, Delta and Omicron variants, and proposed a model of interactions between RBPs and SARS-CoV-2 RNA. It turned out that, despite the generally accepted opinion about the importance of the RBP‒virus interaction, since the onset of the COVID-19 pandemic there has been a gradual decrease in the affinity of RBPs for SARS-CoV-2 RNA.