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Abstract <p>Genetic engineering approach has been used to create a collection of recombinant <i>E. coli</i> strains-producers of bacterial enzymes beta-lactamases related both to the existing natural analogues and to the mutant forms of natural enzymes. Currently, the collection includes beta-lactamases of the TEM (molecular class A), CTX-M (molecular class A), VIM (molecular class B), and NDM (molecular class B) types. A set of recombinant beta-lactamases can be used for screening new antibacterial drugs and inhibitors in vitro. The collection of beta-lactamase producers is included in the National Depository Bank of Live Systems “Noah’s Ark” of the Lomonosov Moscow State University.</p>

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A Collection of Recombinant Beta-Lactamases for Antibacterial Drug Screening

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • V. G. Grigorenko,
  • O. V. Serova,
  • I. P. Andreeva,
  • M. Yu. Rubtsova,
  • A. M. Egorov

摘要

Abstract

Genetic engineering approach has been used to create a collection of recombinant E. coli strains-producers of bacterial enzymes beta-lactamases related both to the existing natural analogues and to the mutant forms of natural enzymes. Currently, the collection includes beta-lactamases of the TEM (molecular class A), CTX-M (molecular class A), VIM (molecular class B), and NDM (molecular class B) types. A set of recombinant beta-lactamases can be used for screening new antibacterial drugs and inhibitors in vitro. The collection of beta-lactamase producers is included in the National Depository Bank of Live Systems “Noah’s Ark” of the Lomonosov Moscow State University.