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<b>Abstract</b>— <p>Inflammatory bowel diseases (IBD) are a group of chronic gastrointestinal tract diseases. The main causes of IBD are believed to be a disruption in the balance of microbiota and function of the intestinal epithelium. The treatment for IBD includes a combination of drugs and dietary nutrition. Until now, there have been no in vitro studies on the functional state and transcriptome of cultured intestinal epithelial cells depending on alimentary factors such as products of dietary therapeutic nutrition and biologically active additives used to correct the functional state of the intestinal barrier. We analyzed the transcriptome of differentiated Caco-2 cells, which modeled the intestinal barrier, and showed that <i>Saccharomyces cerevisiae</i> hydrolysate had a pronounced positive effect on the intestinal epithelium. Thus, this product can be recommended for correction of the microbiome and restoration of functional activity of the intestine in IBD, as well as for prevention of diseases of the gastrointestinal tract.</p>

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Saccharomyces cerevisiae Hydrolysate: Effects on Caco-2 Cell Functionality and Transcriptome

  • 期刊论文

  • 发表日期：

    2025年12月9日

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  • M. Y. Shkurnikov,
  • S. I. Kolesnikov,
  • S. B. Gerasimov,
  • D. S. Gerasimov

摘要

Abstract—

Inflammatory bowel diseases (IBD) are a group of chronic gastrointestinal tract diseases. The main causes of IBD are believed to be a disruption in the balance of microbiota and function of the intestinal epithelium. The treatment for IBD includes a combination of drugs and dietary nutrition. Until now, there have been no in vitro studies on the functional state and transcriptome of cultured intestinal epithelial cells depending on alimentary factors such as products of dietary therapeutic nutrition and biologically active additives used to correct the functional state of the intestinal barrier. We analyzed the transcriptome of differentiated Caco-2 cells, which modeled the intestinal barrier, and showed that Saccharomyces cerevisiae hydrolysate had a pronounced positive effect on the intestinal epithelium. Thus, this product can be recommended for correction of the microbiome and restoration of functional activity of the intestine in IBD, as well as for prevention of diseases of the gastrointestinal tract.