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<b>Abstract</b>— <p>Hybrid hydrogels formed in situ on the wound surface are considered promising materials for reconstruction and therapy. This paper examines the dermo- ex vivo and mucoadhesive properties in vitro, as well as the antibacterial, hemostatic, and wound-healing activity in vitro and in vivo of glycerohydrogels based on chitosan hydrochloride, glucomannan, silicon tetraglycerolate (a sol-gel precursor), and functional additives. When applied to an intact or wounded dermal surface, the gel-forming composition results in the formation of a protective glycerohydrogel coating (gel film) with explicit adhesive and sorption properties forms in situ within 3–5 minutes. This coating exhibits bacteriostatic and haemostatic action, as well as wound-healing activity. In vivo evaluation of the wound-healing effect showed a statistically significant reduction in skin restoration time compared to the control, allowing us to recommend glycerohydrogel films as effective bioresorbable wound dressings.</p>

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Biological Properties of Glycerohydrogels Based on a Mixture of Chitosan Hydrochloride with Glucomannan, Formed In Situ on the Wound Surface

  • 期刊论文

  • 发表日期：

    2026年4月16日

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  • O. N. Malinkina,
  • D. V. Pridankina,
  • A. S. Astankova,
  • A. B. Shipovskaya

摘要

Abstract—

Hybrid hydrogels formed in situ on the wound surface are considered promising materials for reconstruction and therapy. This paper examines the dermo- ex vivo and mucoadhesive properties in vitro, as well as the antibacterial, hemostatic, and wound-healing activity in vitro and in vivo of glycerohydrogels based on chitosan hydrochloride, glucomannan, silicon tetraglycerolate (a sol-gel precursor), and functional additives. When applied to an intact or wounded dermal surface, the gel-forming composition results in the formation of a protective glycerohydrogel coating (gel film) with explicit adhesive and sorption properties forms in situ within 3–5 minutes. This coating exhibits bacteriostatic and haemostatic action, as well as wound-healing activity. In vivo evaluation of the wound-healing effect showed a statistically significant reduction in skin restoration time compared to the control, allowing us to recommend glycerohydrogel films as effective bioresorbable wound dressings.