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<b>Abstract</b>— <p>In recent decades, the interest in <i>Emericellopsis</i> genus as producers of bioactive molecules has increased significantly due to the isolation of new compounds with potential pharmaceutical applications. Evaluation of the spectrum of antibiotic activity has allowed us to choose a promising producer of a new antibacterial compound, the strain <i>Emericellopsis</i> sp. E102 derived from saline soils. Strain E102, based on molecular and phylogenetic constructions, is allocated to a separate clade within the marine clade of <i>Emericellopsis</i> and is presumably a new species. The ethyl acetate extract of the E102 strain demonstrated significant efficacy at a concentration of 1000 μg/mL, resulting in the inhibition zones of 20.3–30.0 mm in size against <i>Escherichia coli</i> ATCC 25922; <i>Escherichia coli</i> ATCC 25922, <i>Klebsiella pneumoniae</i> ATCC 700603, <i>Pseudomonas aeruginosa</i> ATCC 27853, <i>Staphylococcus aureus</i> ATCC 29213 and <i>Enterococcus faecalis</i> ATCC 29212. The high-performance liquid chromatography analysis identified a compound with monoisotopic mass of the substance 724.5 g/mol. Using the Chemcalc.org service, the most probable gross formulas of the required component were determined. Based on the presented calculations, there is a high probability that the substance has a sterane framework.</p>

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Antimicrobial Potential of the Micromycete Emericellopsis sp. E102 and the Influence of Cultivation Conditions on the Biosynthesis of Antibiotics

  • 期刊论文

  • 发表日期：

    2025年9月24日

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  • V. V. Sokolov,
  • I. V. Mironov,
  • A. Yu. Simonov,
  • I. B. Levshin,
  • M. L. Georgieva,
  • V. S. Sadykova

摘要

Abstract—

In recent decades, the interest in Emericellopsis genus as producers of bioactive molecules has increased significantly due to the isolation of new compounds with potential pharmaceutical applications. Evaluation of the spectrum of antibiotic activity has allowed us to choose a promising producer of a new antibacterial compound, the strain Emericellopsis sp. E102 derived from saline soils. Strain E102, based on molecular and phylogenetic constructions, is allocated to a separate clade within the marine clade of Emericellopsis and is presumably a new species. The ethyl acetate extract of the E102 strain demonstrated significant efficacy at a concentration of 1000 μg/mL, resulting in the inhibition zones of 20.3–30.0 mm in size against Escherichia coli ATCC 25922; Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 700603, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212. The high-performance liquid chromatography analysis identified a compound with monoisotopic mass of the substance 724.5 g/mol. Using the Chemcalc.org service, the most probable gross formulas of the required component were determined. Based on the presented calculations, there is a high probability that the substance has a sterane framework.