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Abstract— <p>There are numerous publications indicating an increase in the expression level of heat shock proteins (HSP) in oncological diseases. Therefore, the development of methods for indicating HSP as a marker of oncological diseases is promising. In this work, phage antibodies specific to HSP of a mouse myeloma cell line have been obtained. The effect of the conductivity of the measurement medium on the registration of an analytical signal during the interaction of phage antibodies with HSP has been studied for the first time using a compact acoustic sensor. The possibility of recording specific “HSP–phage antibodies” interaction in suspensions with a conductivity of 50–1180 μS/cm was experimentally established. Control experiments were conducted to assess mass load on the sensor. The results obtained are promising for the development of acoustic sensor systems in HSP indication.</p>

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Indication of Heat Shock Proteins in Conducting Suspensions Using Phage Antibodies and an Acoustic Analyzer

  • 期刊论文

  • 发表日期：

    2025年6月13日

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  • O. I. Guliy,
  • B. D. Zaitsev,
  • I. A. Borodina,
  • S. A. Staroverov,
  • R. D. Vyrshchikov,
  • K. K. Fursova,
  • F. A. Brovko,
  • L. A. Dykman

摘要

Abstract—

There are numerous publications indicating an increase in the expression level of heat shock proteins (HSP) in oncological diseases. Therefore, the development of methods for indicating HSP as a marker of oncological diseases is promising. In this work, phage antibodies specific to HSP of a mouse myeloma cell line have been obtained. The effect of the conductivity of the measurement medium on the registration of an analytical signal during the interaction of phage antibodies with HSP has been studied for the first time using a compact acoustic sensor. The possibility of recording specific “HSP–phage antibodies” interaction in suspensions with a conductivity of 50–1180 μS/cm was experimentally established. Control experiments were conducted to assess mass load on the sensor. The results obtained are promising for the development of acoustic sensor systems in HSP indication.